Protective Effects of Interleukin‐1 Inhibition With Anakinra in Mouse Models of Ischemic Stroke With and Without Reperfusion
The study demonstrates that a high dose of anakinra improves outcomes in mouse models of moderate infarction following ischemia/reperfusion, whereas its effect was less pronounced in a malignant hemispheric infarction model without reperfusion, where only a nonsignificant trend toward protection was observed.
Authors
- Xabier Urra (ORCID: https://orcid.org/0000-0002-4763-5252)
- Carles Justicia (ORCID: https://orcid.org/0000-0003-0969-6158)
- Juan B. Salom (ORCID: https://orcid.org/0000-0002-4162-6101)
- Leire Pedrosa (ORCID: https://orcid.org/0000-0002-1852-4975)
- Nerea Chaparro‐Cabanillas (ORCID: https://orcid.org/0000-0001-9794-534X)
- Jordi Pedragosa (ORCID: https://orcid.org/0000-0001-8493-4545)
- Juan I. Aróstegui (ORCID: https://orcid.org/0000-0003-4757-504X)
- Alicia Aliena‐Valero (ORCID: https://orcid.org/0000-0001-8858-0481)
- Anna M. Planas (ORCID: https://orcid.org/0000-0002-6147-1880)
- Ángel Chamorro (ORCID: https://orcid.org/0000-0002-0392-6285)
- Milagros Honores
- Mercè Rossinyol‐Boladeres
Institutions
- Universitat Autònoma de Barcelona (ES)
- Universitat de València (ES)
- Institut d'Investigacions Biomèdiques de Barcelona (ES)
- Fundació Clínic per a la Recerca Biomèdica (ES)
- Instituto de Investigación Sanitaria La Fe (ES)
- Universitat de Barcelona (ES)
Publication Details
- Journal
- Journal of the American Heart Association
- Published
- 2025-05-02
- DOI
- https://doi.org/10.1161/jaha.124.040474
- Citations
- 4
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 3.37