Three‐dimensional high‐resolution <scp>T<sub>1</sub></scp> mapping and perfusion imaging in the normal and ischemic rat brain with hyperpolarized [2‐<scp><sup>13</sup>C</scp>]<i>tertiary‐</i>butyl alcohol
Hyperpolarized TBA provides sufficient sensitivity and tissue residence time to enable three-dimensional mapping of relaxation and blood flow at 1.2-1.5-mm<sup>3</sup> isotropic resolution in the rat brain. The technique has adequate signal-to-noise ratio in tissue with restricted flow. Raw images of the tracer can be acquired at 0.48 mm<sup>3</sup> isotropic resolution and signal-to-noise ratio of about 13 in cortical gray matter.
Authors
- Aaron K. Grant (ORCID: https://orcid.org/0000-0002-2605-8062)
- Gopal Varma (ORCID: https://orcid.org/0000-0002-7060-1982)
- Cody Callahan (ORCID: https://orcid.org/0000-0002-0267-7096)
- Mauricio Contreras (ORCID: https://orcid.org/0009-0002-9821-8536)
Institutions
- Beth Israel Deaconess Medical Center (US)
- Harvard University (US)
- The University of Texas at Austin (US)
Publication Details
- Journal
- Magnetic Resonance in Medicine
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1002/mrm.30535
- Primary Topic
- Advanced NMR Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health