Amphiregulin Mediates Epithelial Cell–Eosinophil Interactions and Amplifies Inflammation in Chronic Rhinosinusitis With Nasal Polyps
The upregulation of AREG triggers eosinophil migration and mediates the interaction between epithelial cells and eosinophils, thereby enhancing chronic inflammation in CRSwNP. Our study highlights the therapeutic potential of anti-AREG antibodies in CRSwNP, offering a promising strategy for treating human eosinophilic sinus diseases.
Authors
- Chengshuo Wang (ORCID: https://orcid.org/0000-0003-0646-5135)
- Yan Li (ORCID: https://orcid.org/0000-0001-6061-2170)
- Luo Zhang (ORCID: https://orcid.org/0000-0002-0910-9884)
- Zaichuan Wang (ORCID: https://orcid.org/0000-0001-6339-3380)
- Claus Bachert (ORCID: https://orcid.org/0000-0003-4742-1665)
- Shujian Zhang (ORCID: https://orcid.org/0000-0003-3216-722X)
- Nan Zhang (ORCID: https://orcid.org/0000-0003-0679-6188)
- Feng Lan (ORCID: https://orcid.org/0009-0003-5916-1431)
- Yuling Zhang (ORCID: https://orcid.org/0000-0002-9050-7045)
- Qiqi Wang (ORCID: https://orcid.org/0000-0001-8633-1342)
- Zhennan Qu
- Limin Zhao
- Yingyue Liu
- Yushi Guo
Institutions
- Beijing Tongren Hospital (CN)
- Capital Medical University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- University Hospital Münster (DE)
- Beijing Municipal Education Commission (CN)
Publication Details
- Journal
- Allergy
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1111/all.16582
- Citations
- 1
- Primary Topic
- Sinusitis and nasal conditions
- Type
- article
- Field-Weighted Citation Impact
- 1.85
Funders
- National Natural Science Foundation of China
- Beijing Nova Program