Nickel/Photoredox Dual-Catalyzed, Regioselective 1,2-Carboacylation of Alkenes via Synergistic Alkyl and Benzoyl Radical Coupling

A regioselective 1,2-carboacylation protocol of alkenes via nickel/photoredox dual catalysis has been successfully developed under mild conditions. A wide range of alkyl bromides, α-oxocarboxylic acids, and styrenes proved to be compatible under the optimized conditions, affording the corresponding 1,2-carboacylation products in up to 91% yields. Mechanistically, the key to the success of this approach is the temporal orchestration of radical generation: nickel-catalyzed halogen atom transfer (XAT) for alkyl bromides and photoredox-driven decarboxylation for α-oxocarboxylic acids.