1H, 13C and 15N resonance assignments for the acetyltransferase domain of the kinetoplastid kinetochore protein KKT23 from Trypanosoma brucei
KKT23 is a kinetoplastid-specific kinetochore protein that has a C-terminal GCN5-related histone acetyltransferase domain that acetylates the C-terminal tail of histone H2A. Here, we present the <sup>1</sup>H, <sup>13</sup>C and <sup>15</sup>N resonance assignments for the C-terminal region of KKT23 (KKT23<sup>125-348</sup>) from Trypanosoma brucei in complex with known cofactors for acetyltransferases, acetyl coenzyme A and coenzyme A. These assignments provide the starting point for detailed investigation of the structure, dynamics and interactions of KKT23 in solution.
Authors
- Patryk Ludzia (ORCID: https://orcid.org/0000-0002-1678-6875)
- Bungo Akiyoshi (ORCID: https://orcid.org/0000-0001-6010-394X)
- Christina Redfield (ORCID: https://orcid.org/0000-0001-7297-7708)
- Courtney Nugent
Institutions
- University of Cambridge (GB)
- University of Oxford (GB)
Publication Details
- Journal
- Biomolecular NMR Assignments
- Published
- 2025-05-02
- DOI
- https://doi.org/10.1007/s12104-025-10235-4
- Primary Topic
- Trypanosoma species research and implications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Wellcome Trust
- University of Oxford
- Boehringer Ingelheim Fonds
- Engineering and Physical Sciences Research Council
- John Fell Fund, University of Oxford