Ligand-Enabled Palladium-Catalyzed β-C(sp<sup>3</sup>)–H Biarylation of Native Amides with Cyclic Diaryliodonium Salts
Herein, we report a Pd-catalyzed β-C(sp<sup>3</sup>)-H biarylation of native amides using diaryliodonium salts. A pyridine-3-sulfonic acid ligand that might stabilize the substrate-bound palladium species was found to be essential for high catalytic activity. The reaction displayed a broad scope and showed excellent compatibility with diverse cyclic diaryliodonium salts and amide substrates. The retained iodo functionality on the product provides a versatile handle for further increasing molecular complexity.
Authors
- Biplab Maji (ORCID: https://orcid.org/0000-0001-5034-423X)
- Animesh Das (ORCID: https://orcid.org/0000-0002-9019-5678)
- Mohit Chotia
Institutions
- Indian Institute of Science Education and Research Kolkata (IN)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-05-02
- DOI
- https://doi.org/10.1021/acs.orglett.5c01313
- Citations
- 1
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- Indian Institute of Science Education and Research Kolkata
- Science and Engineering Research Board