Induced pluripotent stem cell-derived mesenchymal stem cells (iMSCs) inhibit M1 macrophage polarization and reduce alveolar bone loss associated with periodontitis
iMSCs demonstrate significant therapeutic potential in periodontitis by modulating macrophage polarization, reducing oxidative stress, and mitigating alveolar bone loss associated with the disease. These findings provide new insights into the mechanisms of iMSCs and their application as cell-based therapies for periodontal diseases.
Authors
- Qingxian Luan (ORCID: https://orcid.org/0000-0003-0209-8622)
- Yiming Ma (ORCID: https://orcid.org/0000-0003-2099-8077)
- Yiran Geng
- Liang Chen (ORCID: https://orcid.org/0000-0003-4895-6506)
- Jia Liu (ORCID: https://orcid.org/0000-0002-2070-7754)
- Yong Zhang (ORCID: https://orcid.org/0000-0002-1303-0458)
- Yang Li (ORCID: https://orcid.org/0000-0002-5882-2301)
- Chenhao Yu (ORCID: https://orcid.org/0009-0009-9336-3997)
- Yu Cai (ORCID: https://orcid.org/0000-0002-6156-485X)
- Yuanqing Liu (ORCID: https://orcid.org/0009-0009-1223-6639)
- Pei Cao (ORCID: https://orcid.org/0000-0002-4240-5124)
Institutions
- Peking University (CN)
- National Clinical Research (US)
- Stomatology Hospital (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-05-02
- DOI
- https://doi.org/10.1186/s13287-025-04327-0
- Citations
- 8
- Primary Topic
- Mesenchymal stem cell research
- Type
- article
- Field-Weighted Citation Impact
- 13.00
Funders
- National Natural Science Foundation of China