The VEGF decoy receptor soluble Fms-like tyrosine kinase 1 binds to macrophages
Our results show that sFLT1, while typically associated with angiogenesis, also directly interacts with macrophages. Alternative activation of macrophages by IL-4 strongly increases binding of sFLT1 to the cell surface membrane, possibly via the VEGF co-receptor neuropilin-1. Considering sFLT1's anti-inflammatory effects in animal studies, our findings indicate a novel function for sFLT1 to directly control anti-inflammatory macrophage function.
Authors
- Hans J. Baelde (ORCID: https://orcid.org/0000-0002-1214-500X)
- Peter A. van Veelen (ORCID: https://orcid.org/0000-0002-7898-9408)
- Arnoud H. de Ru (ORCID: https://orcid.org/0009-0002-1166-4059)
- Jan A. Bruijn (ORCID: https://orcid.org/0000-0001-7592-250X)
- Kyra L. Dijkstra (ORCID: https://orcid.org/0000-0002-6181-3983)
- Ron Wolterbeek
- Samiksha Sardana (ORCID: https://orcid.org/0000-0003-3621-8418)
- Hailiang Mei (ORCID: https://orcid.org/0000-0003-1781-5508)
- Cees van Kooten (ORCID: https://orcid.org/0000-0002-6257-0899)
- Cleo C. L. van Aanhold (ORCID: https://orcid.org/0000-0001-7760-7781)
- Rayman T.N. Tjokrodirijo (ORCID: https://orcid.org/0009-0007-4878-8385)
- Lisa Landman
- Qing Yong (ORCID: https://orcid.org/0000-0003-0437-271X)
- Anouk B Bouwmeester
Institutions
- Radboud University Nijmegen (NL)
- Utrecht University (NL)
- Leiden University Medical Center (NL)
- Radboud University Medical Center (NL)
- Netherlands Metabolomics Centre (NL)
Publication Details
- Journal
- Angiogenesis
- Published
- 2025-05-02
- DOI
- https://doi.org/10.1007/s10456-025-09980-w
- Citations
- 1
- Primary Topic
- Pregnancy and preeclampsia studies
- Type
- article
- Field-Weighted Citation Impact
- 2.06