A tale of two parasites: a glimpse into the RNA methylome of patient-derived Plasmodium falciparum and Plasmodium vivax isolates
The data shows the presence of modified sense, NATs and alternatively spliced transcripts. These phenomena together suggest the presence of multiple regulatory layers which decides the post-translational proteome of the parasites in particular disease conditions. Studies like these will help to decipher the post-translational environments of malaria parasites in vivo and elucidate their inherent proteome plasticity, thus allowing the conceptualization of novel strategies for interventions.
Authors
- Priyanka Roy (ORCID: https://orcid.org/0000-0001-9450-9649)
- Ishaan Gupta (ORCID: https://orcid.org/0000-0001-8934-9919)
- Ashis Das (ORCID: https://orcid.org/0000-0001-9255-1827)
- Dinesh Gupta (ORCID: https://orcid.org/0000-0001-9108-9669)
- Tanmaya Mahapatra (ORCID: https://orcid.org/0000-0002-7946-5497)
- Sukriti Gujarati
- Pallavi Gupta (ORCID: https://orcid.org/0000-0001-6004-2876)
- Sanjay Kumar Kochar
- Dhanpat Kumar Kochar
Institutions
- The University of Queensland (AU)
- Sardar Patel Medical College (IN)
- International Centre for Genetic Engineering and Biotechnology (IN)
- Indian Institute of Technology Delhi (IN)
- Birla Institute of Technology and Science, Pilani (IN)
Publication Details
- Journal
- Malaria Journal
- Published
- 2025-05-02
- DOI
- https://doi.org/10.1186/s12936-025-05376-9
- Citations
- 2
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- Department of Biotechnology, Ministry of Science and Technology, India
- Indian Council of Medical Research
- International Centre for Genetic Engineering and Biotechnology
- Ministry of Education, India
- Birla Institute of Technology and Science, Pilani
- Division of Human Resource Development