Photoredox-Catalyzed Trifluoromethylamination of Alkenes with Concomitant Introduction of a Quinoxalin-2(1<i>H</i>)-one Moiety
A photoredox-catalyzed strategy for the difunctionalization of alkenes with quinoxalin-2(1<i>H</i>)-ones and <i>N</i>-CF<sub>3</sub> hydroxylamine reagents was developed. This reaction was carried out under photoirradiation conditions, affording the corresponding three-component coupling products in moderate to high yields with excellent regioselectivity. It provides a new protocol to access valuable quinoxalin-2(1<i>H</i>)-one derivatives containing a <i>N</i>-CF<sub>3</sub> group.
Authors
- Yangen Huang (ORCID: https://orcid.org/0000-0002-2608-7728)
- Meiyu Zhang (ORCID: https://orcid.org/0000-0002-9263-2798)
- Shuai Liu (ORCID: https://orcid.org/0009-0006-3307-2838)
- Weidong Meng (ORCID: https://orcid.org/0000-0003-3434-9369)
Institutions
- Donghua University (CN)
- Chemical Synthesis Lab (SG)
- Jiangxi Normal University (CN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2025-05-02
- DOI
- https://doi.org/10.1021/acs.joc.5c00400
- Citations
- 3
- Primary Topic
- Fluorine in Organic Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 2.37
Funders
- National Natural Science Foundation of China