Apigenin mitigates oxidative stress, neuroinflammation, and cognitive impairment but enhances learning and memory in aluminum chloride‐induced neurotoxicity in rats
Aluminum chloride toxicity caused significant reduction in learning, exploration, and memory. Aluminum chloride toxicity induced neurotoxicity, increased biomarkers of oxidative stress, neuroinflammation, and precipitated cognitive impairment. Apigenin improved brain antioxidant, enhanced learning, exploration, and memory.
Authors
- Temitayo Olabisi Ajibade (ORCID: https://orcid.org/0000-0003-1971-8621)
- Adewumi Victoria Adeogun
- Adedunsola Adewunmi Obasa (ORCID: https://orcid.org/0009-0001-4840-8190)
- Ishmael Festus Jaja (ORCID: https://orcid.org/0000-0002-9310-6511)
- Temidayo Olutayo Omóbòwálé (ORCID: https://orcid.org/0000-0002-9486-2861)
- Oluwaseun Olanrewaju Esan (ORCID: https://orcid.org/0000-0002-9933-876X)
- Olufunke Eunice Ola‐Davies (ORCID: https://orcid.org/0000-0003-4388-8700)
- Ademola Adetokunbo Oyagbemi (ORCID: https://orcid.org/0000-0002-8996-8610)
- Olumayowa Olawumi Igado
- Omowumi Femi‐Akinlosotu (ORCID: https://orcid.org/0000-0002-9933-155X)
- Joseph Emmanuel Ikokide
- Adeola Temitope Salami (ORCID: https://orcid.org/0000-0002-6535-1747)
- Momoh Audu Yakubu (ORCID: https://orcid.org/0000-0002-6072-2473)
- Oluwafemi Omoniyi Oguntibeju (ORCID: https://orcid.org/0000-0002-7299-1128)
- Taiwo Olaide Oyagbemi (ORCID: https://orcid.org/0000-0003-0306-6219)
- Evaristus Nwulia (ORCID: https://orcid.org/0000-0003-3492-882X)
- Adebowale Bernard Saba
- Omolola Victoria Awoyomi
- Charles Etang Onukak
- Moses Semilore Ojo
Institutions
- University of Fort Hare (ZA)
- Cape Peninsula University of Technology (ZA)
- University of South Africa (ZA)
- University of Ibadan (NG)
- Howard University Hospital (US)
- Texas Southern University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1002/alz.70223
- Citations
- 9
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 10.48