Enhanced oral bioavailability of two Cistanche polysaccharides in acteoside: an in-depth analysis of intestinal flora, short-chain fatty acids, and pharmacokinetic regulation
By exploring the synergistic effects of large molecules Cistanche polysaccharides and small molecule acteoside, this paper provides a new explanation for the scientific use of plant-derived polysaccharides to improve the bioavailability of oral drugs.
Authors
- Ji Shi (ORCID: https://orcid.org/0000-0002-6409-4662)
- Jing Lian (ORCID: https://orcid.org/0000-0001-9753-1980)
- Guoshun Shan (ORCID: https://orcid.org/0000-0002-1248-6517)
- Kuntian Dong
- Fan Zhang (ORCID: https://orcid.org/0000-0003-3291-7887)
- Pengpeng Liu (ORCID: https://orcid.org/0000-0001-6515-4682)
- Yuan Zhang (ORCID: https://orcid.org/0000-0001-5699-7960)
- Jia Tian-zhu (ORCID: https://orcid.org/0000-0002-6529-4025)
- Nan Wang
Institutions
- State Administration of Traditional Chinese Medicine of the People's Republic of China (CN)
- Liaoning University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Frontiers in Nutrition
- Published
- 2025-05-02
- DOI
- https://doi.org/10.3389/fnut.2025.1509734
- Citations
- 6
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 4.84
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Liaoning Province