Reduced myelin contributes to cognitive impairment in patients with monogenic small vessel disease
χ-negative magnetic resonance signal was reduced within white matter hyperintensities and normal appearing white matter in patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy, suggesting widespread myelin decreases due to cerebral small vessel disease (cSVD). χ-negative values were only moderately associated with diffusion tensor imaging derived indices including free water and mean diffusivity, suggesting that χ separation depicts distinct microstructural changes in cSVD. Alterations in χ-negative values made a unique contribution to explain processing speed impairment, even when controlled for diffusion and iron changes.
Authors
- Carolina C. S. Valentim (ORCID: https://orcid.org/0000-0003-4203-6856)
- Anna Dewenter (ORCID: https://orcid.org/0000-0002-5636-196X)
- Anna Kopczak (ORCID: https://orcid.org/0000-0002-5037-2342)
- Lukas Pirpamer (ORCID: https://orcid.org/0000-0002-4390-9703)
- Michael Ewers (ORCID: https://orcid.org/0000-0001-5231-1714)
- Martin Dichgans (ORCID: https://orcid.org/0000-0002-0654-387X)
- Benno Gesierich (ORCID: https://orcid.org/0000-0003-2842-7105)
- Nicolai Franzmeier (ORCID: https://orcid.org/0000-0001-9736-2283)
- Marco Duering (ORCID: https://orcid.org/0000-0003-2302-3136)
- Jong-Ho Lee (ORCID: https://orcid.org/0000-0002-8843-545X)
- J. Denecke
Institutions
- University of Basel (CH)
- German Center for Neurodegenerative Diseases (DE)
- LMU Klinikum (DE)
- Munich Cluster for Systems Neurology (DE)
- Ludwig-Maximilians-Universität München (DE)
- University of Gothenburg (SE)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1002/alz.70127
- Citations
- 6
- Primary Topic
- Cerebrovascular and genetic disorders
- Type
- article
- Field-Weighted Citation Impact
- 8.34
Funders
- European Commission
- Bundesministerium für Bildung und Forschung
- HORIZON EUROPE Framework Programme