Modular Assembly of Axially Chiral QUINAP Derivatives via Nickel-Catalyzed Enantioselective C–P Cross-Coupling

QUINAPs represent a powerful class of ligands with broad applications in a diverse array of synthetically important asymmetric transformations. However, their broader utilization is often constrained by a limited substrate scope and high cost associated with their multistep synthesis. Consequently, a highly efficient dynamic kinetic asymmetric transformation of N-heterobiaryl derivatives has been developed through Ni-catalyzed asymmetric C–P cross-coupling. This method provides versatile access to a wide range of substituted QUINAP derivatives with good yields and high enantioselectivities, which are successfully applied in both transition-metal catalysis and organocatalysis.