Formate-Mediated C–C Coupling of Aryl/Vinyl Halides and Triflates: Carbonyl Arylation and Reductive Cross-Coupling
Catalytic methods for the intermolecular formate-mediated C-C coupling of Csp<sup>2</sup>-X pronucleophiles beyond reductive Heck reactions (alkene hydroarylations) are catalogued. These methods include transfer hydrogenative reductive couplings of aryl/vinyl halides or triflates to carbonyl compounds (Grignard/NHK-type reactions), as well as reductive cross-couplings of two aryl/vinyl halide or triflate partners. These studies demonstrate that reactions traditionally associated with discrete Csp<sup>2</sup> carbanions can be rendered catalytic and free from premetalated reagents or metallic reductants using sodium or potassium formate - abundant, low molecular weight sources of hydrogen.
Authors
- Yu-Hsiang Chang (ORCID: https://orcid.org/0000-0003-1000-135X)
- Weijia Shen (ORCID: https://orcid.org/0000-0001-6345-3371)
- Michael J. Krische (ORCID: https://orcid.org/0000-0001-8418-9709)
- Yoon Cho (ORCID: https://orcid.org/0000-0002-3550-6699)
Institutions
- The University of Texas at Austin (US)
Publication Details
- Journal
- ACS Catalysis
- Published
- 2025-05-02
- DOI
- https://doi.org/10.1021/acscatal.5c01994
- Citations
- 3
- Primary Topic
- Asymmetric Hydrogenation and Catalysis
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- Welch Foundation
- National Institute of General Medical Sciences