Respiratory syncytial virus–related lower respiratory tract infection hospitalizations in infants receiving nirsevimab in Galicia (Spain): the NIRSE-GAL study
• During the first RSV season after the universal implementation of nirsevimab in Galicia (Spain), a large proportion of hospitalized infants had high-risk conditions, yet disease severity markers (oxygen need, ICU admission, NIVM) were comparable between breakthrough and non-breakthrough cases. • No signal of waning protection over time was observed among breakthrough cases, reinforcing the potential value of early, season-wide immunization.
Authors
- Antonio Salas (ORCID: https://orcid.org/0000-0002-2336-702X)
- Narmeen Mallah (ORCID: https://orcid.org/0000-0002-3711-3792)
- Rolf Kramer (ORCID: https://orcid.org/0000-0002-6095-4338)
- Ángela Manzanares (ORCID: https://orcid.org/0000-0002-4230-5035)
- Victoria Nartallo‐Penas (ORCID: https://orcid.org/0000-0002-9938-9436)
- Marta Piñeiro-Sotelo
- Carmen Durán‐Parrondo
- Jacobo Pardo‐Seco (ORCID: https://orcid.org/0000-0002-8059-8908)
- Juan‐Manuel González‐Pérez
- Federico Martinón‐Torres (ORCID: https://orcid.org/0000-0002-9023-581X)
- Ana Dacosta-Urbieta (ORCID: https://orcid.org/0000-0002-8803-957X)
- Olaia Pérez‐Martínez (ORCID: https://orcid.org/0000-0002-6743-2380)
- María‐Teresa Otero‐Barrós (ORCID: https://orcid.org/0000-0002-4180-545X)
- Irene Rivero‐Calle (ORCID: https://orcid.org/0000-0002-3678-9264)
- Susana Mirás‐Carballal (ORCID: https://orcid.org/0009-0009-5185-4421)
- Leticia Platero-Alonso
- Rosa‐María Alvárez‐Gil
- Olga‐María Ces‐Ozores
- Nuria Súarez‐Gaiche
- Jing Jin (ORCID: https://orcid.org/0000-0003-3994-8600)
- Carmen Rodríguez‐Tenreiro (ORCID: https://orcid.org/0000-0003-1142-2818)
- María-Isolina Santiago-Pérez
Institutions
- Universidade de Santiago de Compostela (ES)
- Xunta de Galicia (ES)
- Instituto de Salud Carlos III (ES)
- Sanofi (France) (FR)
- Complejo Hospitalario Universitario de Santiago (ES)
- Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (ES)
- Instituto de Investigación Sanitaria de Santiago (ES)
- Servicio Gallego de Salud (ES)
Publication Details
- Journal
- European Journal of Pediatrics
- Published
- 2025-05-02
- DOI
- https://doi.org/10.1007/s00431-025-06151-3
- Citations
- 4
- Primary Topic
- Respiratory viral infections research
- Type
- article
- Field-Weighted Citation Impact
- 5.42
Funders
- AstraZeneca
- Sanofi
- Ministerio de Ciencia e Innovación
- Xunta de Galicia
- Universidade de Santiago de Compostela
- European Regional Development Fund
- Servicio Gallego de Salud