RNA-Seq Study of Human Lens Epithelial Cells: Differentially Expressed Genes and Pathways in Steroid, Uveitic, Post-Vitrectomy, and Senile Cataracts
To our knowledge, this is the first large-scale gene expression study focusing on these secondary cataracts. This dataset will assist in forming a broader knowledge base of secondary cataract pathogenesis and inform future research in this area, particularly in the selection of specific genes and investigating their impact on cataract development through animal model studies.
Authors
- Michael Dong (ORCID: https://orcid.org/0000-0001-7044-6030)
- Sean Byars (ORCID: https://orcid.org/0000-0002-3797-8112)
- Anthony J. Hall (ORCID: https://orcid.org/0000-0003-1760-3759)
- Carrie Fei (ORCID: https://orcid.org/0009-0002-1042-6788)
- Lyndell L. Lim (ORCID: https://orcid.org/0000-0003-2491-685X)
- Jaynish S. Shah (ORCID: https://orcid.org/0000-0002-1089-7355)
Institutions
- The University of Melbourne (AU)
- The Alfred Hospital (AU)
- The Royal Victorian Eye & Ear Hospital (AU)
- Centre for Eye Research Australia (AU)
- Australian Centre for HIV and Hepatitis Virology Research (AU)
- Alfred Health (AU)
- Monash University (AU)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-05-02
- DOI
- https://doi.org/10.1167/iovs.66.5.4
- Citations
- 1
- Primary Topic
- Connexins and lens biology
- Type
- article
- Field-Weighted Citation Impact
- 0.81