Plasma biomarkers of amyloid, tau & neuroinflammation in Alzheimer’s disease and corticobasal syndrome
This study highlights the diagnostic utility of pTau181, ApoE4 and the Aβ1-42/1-40 ratio for AD and NfL in the CBS-Aβ(-) cases and emphasizes the added value of combined biomarker models for group differentiation. Prospective studies will help validate these findings and refine clinical thresholds.
Authors
- Oliver Pogarell (ORCID: https://orcid.org/0000-0001-6455-4190)
- Maia Tatò
- Robert Perneczky (ORCID: https://orcid.org/0000-0003-1981-7435)
- Endy Weidinger (ORCID: https://orcid.org/0009-0003-6679-7788)
- Boris Papazov (ORCID: https://orcid.org/0000-0002-5274-9166)
- Sophia Stoecklein (ORCID: https://orcid.org/0000-0003-0325-4674)
- Sayuri Hortsch
- Boris‐Stephan Rauchmann (ORCID: https://orcid.org/0000-0003-4547-6240)
- Johannes Levin (ORCID: https://orcid.org/0000-0001-5092-4306)
- Carla Palleis (ORCID: https://orcid.org/0000-0002-4331-8145)
- Daniel Keeser (ORCID: https://orcid.org/0000-0002-0244-1024)
- Alexander Jethwa (ORCID: https://orcid.org/0000-0003-3869-8662)
- Lena Burow
- Matthias Brendel (ORCID: https://orcid.org/0000-0002-9247-2843)
- Laura De Carli (ORCID: https://orcid.org/0000-0003-4420-6433)
- Estrella Morenas‐Rodríguez (ORCID: https://orcid.org/0000-0002-7591-6051)
- Jan Haeckert (ORCID: https://orcid.org/0000-0002-4319-5034)
- Carolin Kurz (ORCID: https://orcid.org/0000-0003-4299-6240)
- Carolin Koriath (ORCID: https://orcid.org/0000-0003-1066-4938)
- Günter U. Höglinger (ORCID: https://orcid.org/0000-0001-7587-6187)
- Isabelle Schrurs
- Selim Üstün Gürsel
- Julia Utecht
- Margherita Carboni (ORCID: https://orcid.org/0000-0003-0426-8242)
- Tobias Bittner (ORCID: https://orcid.org/0000-0001-9256-0360)
Institutions
- Roche (Switzerland) (CH)
- University of Augsburg (DE)
- German Center for Neurodegenerative Diseases (DE)
- Hospital de Sant Pau (ES)
- University Hospital Augsburg (DE)
- LMU Klinikum (DE)
- Roche Pharma AG (Germany) (DE)
- Munich Cluster for Systems Neurology (DE)
- Bezirkskrankenhaus Augsburg (DE)
- Imperial College London (GB)
- Ludwig-Maximilians-Universität München (DE)
- University of Sheffield (GB)
Publication Details
- Journal
- European Archives of Psychiatry and Clinical Neuroscience
- Published
- 2025-05-02
- DOI
- https://doi.org/10.1007/s00406-025-02013-z
- Citations
- 7
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 8.15
Funders
- Deutsche Forschungsgemeinschaft
- Helmholtz Association