Histopathology of Nonsexually Transmitted Ulcers in Sexually Active Women: 2 Cases

Lipschütz ulcers represent an acute, painful, nonsexually transmitted ulceration on genital skin that has been linked to Epstein-Barr virus, cytomegalovirus, mumps, some salmonella species, toxoplasmosis, mycoplasma, ureaplasma, and other infective agents. Lipschütz ulcers in young sexually inactive and sexually active women are often underdiagnosed, and the work-up leads to significant patient and caregiver distress because the focus is often on sexually transmitted infections. Here we describe 2 young sexually active female patients with nonsexually acquired vulvar ulcerations secondary to mycoplasma and ureaplasma infection with corresponding histopathology findings and a representative clinical image.