Construction of safer hirudin-derived peptides with enhanced anticoagulant properties based on C-terminal active residue adaptation and modification
These findings provide an initial foundation and sequence reference for the development of safe and effective anticoagulant drugs with potential for clinical translation.
Authors
- Xiaozhe Yi
- Xin Chang (ORCID: https://orcid.org/0000-0002-4076-9522)
- Linchun Shi
- Erhuan Zang
- Xiaoli He (ORCID: https://orcid.org/0000-0001-7710-4981)
- Xiaoli Wu (ORCID: https://orcid.org/0009-0005-5116-6128)
- Jinxin Liu (ORCID: https://orcid.org/0000-0002-5302-866X)
Institutions
- Minzu University of China (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- State Administration of Traditional Chinese Medicine of the People's Republic of China (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2025-05-02
- DOI
- https://doi.org/10.1016/j.jare.2025.04.045
- Primary Topic
- Peptidase Inhibition and Analysis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Chinese Academy of Meteorological Sciences
- Natural Science Foundation of Beijing Municipality
- Chinese Academy of Medical Sciences
- China Academy of Chinese Medical Sciences