Epidemiological and genomic characterisation of an outbreak of Streptococcus pyogenes emm5.23
Although genomic traits known to increase GAS virulence potential were not found, polymorphisms that may affect the emm5.23 phenotype were detected. This suggests this emm5.23 genotype was transiently successful rather than hypervirulent, with low population-level immunity contributing to its spread. This study emphasises the need for integration of real-time genomic data in public health surveillance to enhance source attribution and guide interventions.
Authors
- Davide Pagnossin (ORCID: https://orcid.org/0000-0001-8646-3003)
- Juliana Coelho (ORCID: https://orcid.org/0000-0002-4514-3449)
- William Weir (ORCID: https://orcid.org/0000-0001-8648-666X)
- Eisin McDonald (ORCID: https://orcid.org/0000-0001-8766-9767)
- Andrew Smith (ORCID: https://orcid.org/0000-0003-0580-4078)
- Katarína Oravcová (ORCID: https://orcid.org/0000-0001-5930-6803)
- Roisin Ure (ORCID: https://orcid.org/0000-0002-5957-6341)
Institutions
- Public Health Scotland (GB)
- UK Health Security Agency (GB)
- University of Glasgow (GB)
Publication Details
- Journal
- Journal of Infection
- Published
- 2025-05-02
- DOI
- https://doi.org/10.1016/j.jinf.2025.106498
- Citations
- 1
- Primary Topic
- Streptococcal Infections and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.88
Funders
- University of Glasgow
- School of Veterinary Medicine, University of Glasgow