Leveraging long context in retrieval augmented language models for medical question answering

While holding great promise for improving and facilitating healthcare through applications of medical literature summarization, large language models (LLMs) struggle to produce up-to-date responses on evolving topics due to outdated knowledge or hallucination. Retrieval-augmented generation (RAG) is a pivotal innovation that improves the accuracy and relevance of LLM responses by integrating LLMs with a search engine and external sources of knowledge. However, the quality of RAG responses can be largely impacted by the rank and density of key information in the retrieval results, such as the "lost-in-the-middle" problem. In this work, we aim to improve the robustness and reliability of the RAG workflow in the medical domain. Specifically, we propose a map-reduce strategy, BriefContext, to combat the "lost-in-the-middle" issue without modifying the model weights. We demonstrated the advantage of the workflow with various LLM backbones and on multiple QA datasets. This method promises to improve the safety and reliability of LLMs deployed in healthcare domains by reducing the risk of misinformation, ensuring critical clinical content is retained in generated responses, and enabling more trustworthy use of LLMs in critical tasks such as medical question answering, clinical decision support, and patient-facing applications.

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Publication Details

Journal
npj Digital Medicine
Published
2025-05-02
DOI
https://doi.org/10.1038/s41746-025-01651-w
Citations
37
Primary Topic
Topic Modeling
Type
article
Field-Weighted Citation Impact
89.31

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article

Leveraging long context in retrieval augmented language models for medical question answering

Gongbo Zhang, Chunhua Weng, Ziyang Xu, Justin F. Rousseau et al.
37 citations
npj Digital Medicine
Topic Modeling
89.31
article

Leveraging long context in retrieval augmented language models for medical question answering

Gongbo Zhang, Chunhua Weng, Ziyang Xu, Justin F. Rousseau, Zihan Xu, Yilu Fang, Fangyi Chen, Yifan Peng, Yi Liu, Zhiyong Lu, Qiao Jin
article en
37 citations

Abstract

While holding great promise for improving and facilitating healthcare through applications of medical literature summarization, large language models (LLMs) struggle to produce up-to-date responses on evolving topics due to outdated knowledge or hallucination. Retrieval-augmented generation (RAG) is a pivotal innovation that improves the accuracy and relevance of LLM responses by integrating LLMs with a search engine and external sources of knowledge. However, the quality of RAG responses can be largely impacted by the rank and density of key information in the retrieval results, such as the "lost-in-the-middle" problem. In this work, we aim to improve the robustness and reliability of the RAG workflow in the medical domain. Specifically, we propose a map-reduce strategy, BriefContext, to combat the "lost-in-the-middle" issue without modifying the model weights. We demonstrated the advantage of the workflow with various LLM backbones and on multiple QA datasets. This method promises to improve the safety and reliability of LLMs deployed in healthcare domains by reducing the risk of misinformation, ensuring critical clinical content is retained in generated responses, and enabling more trustworthy use of LLMs in critical tasks such as medical question answering, clinical decision support, and patient-facing applications.

npj Digital MedicineVol. 8(1)
National Institutes of Health (US), Cornell University (US), United States National Library of Medicine (US), Weill Cornell Medicine (US), New York University (US), Columbia University (US), The University of Texas Southwestern Medical Center (US)
Amazon Web Services, National Institutes of Health, U.S. National Library of Medicine
Quality Education
Openalex Percentile: Top 0%
Topic Modeling
89.31
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