A Rare Case of Male Breast Cancer Presenting as a Superficial Pigmented Nipple Tumor: The Importance of a Deep Excisional Biopsy and Immunohistochemical Analysis in Diagnosis

Nipple lesions present diagnostic challenges due to overlapping clinical and histopathological features. A 65-year-old male presented with a black skin lesion on his right nipple, initially suspected to be malignant melanoma. Dermoscopy suggested basal cell carcinoma, while punch biopsy findings indicated sweat gland carcinoma with negative mammaglobin staining. However, total resection revealed cord-like invasion into the deep dermis near the mammary gland, and immunohistochemistry showed mammaglobin positivity, leading to a final diagnosis of solid-type invasive ductal carcinoma of the breast. This case highlights the diagnostic challenges of male nipple tumors and underscores the need for thorough histopathological and deep-layer assessment to distinguish breast cancer from cutaneous malignancies.

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Journal
Cureus
Published
2025-05-02
DOI
https://doi.org/10.7759/cureus.83353
Primary Topic
Cancer and Skin Lesions
Type
article
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0.00
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article

A Rare Case of Male Breast Cancer Presenting as a Superficial Pigmented Nipple Tumor: The Importance of a Deep Excisional Biopsy and Immunohistochemical Analysis in Diagnosis

Yutaka Hatano, Takashi Sakai, Atsushi Osoegawa, Ryo Nishiyori et al.
Cureus
Cancer and Skin Lesions
article

A Rare Case of Male Breast Cancer Presenting as a Superficial Pigmented Nipple Tumor: The Importance of a Deep Excisional Biopsy and Immunohistochemical Analysis in Diagnosis

Yutaka Hatano, Takashi Sakai, Atsushi Osoegawa, Ryo Nishiyori, Yuzo Oyama, Ryo Furukawa, Yohei Takumi, Mayuko Goto-Umeki, Mizuho Fujinaga‐Tada
article en

Abstract

Nipple lesions present diagnostic challenges due to overlapping clinical and histopathological features. A 65-year-old male presented with a black skin lesion on his right nipple, initially suspected to be malignant melanoma. Dermoscopy suggested basal cell carcinoma, while punch biopsy findings indicated sweat gland carcinoma with negative mammaglobin staining. However, total resection revealed cord-like invasion into the deep dermis near the mammary gland, and immunohistochemistry showed mammaglobin positivity, leading to a final diagnosis of solid-type invasive ductal carcinoma of the breast. This case highlights the diagnostic challenges of male nipple tumors and underscores the need for thorough histopathological and deep-layer assessment to distinguish breast cancer from cutaneous malignancies.

CureusVol. 17(5)
Oita University (JP)
Gender equality
Openalex Percentile: Top 82%
Cancer and Skin Lesions
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A Rare Case of Male Breast Cancer Presenting as a Superficial Pigmented Nipple Tumor: The Importance of a Deep Excisional Biopsy and Immunohistochemical Analysis in Diagnosis — Yutaka Hatano, Takashi Sakai, et al. · Cureus (2025) | TGRS Research Map | TGRS