Fenugreek-enriched electrospun PLA scaffold: revolutionizing tissue engineering solutions

Abstract The therapeutic properties of medicinal plants have been harnessed to facilitate wound healing, and conventional techniques for their application in this regard have been devised. Electrospun nanofibrous scaffolds have recently shown great potential as materials for tissue engineering, specifically tissue regeneration. Utilizing medicinal plant components in nanofibers for biomedical and wound healing purposes holds promise for improving performance and achieving a synergistic outcome. The scaffolds that were created underwent analysis using X-ray diffraction, Fourier transform, mechanical testing, swelling measurement, contact angle measurement, and weight loss assessment. The study also examined the compatibility of the cells with the scaffolds and assessed their wound-healing capacity in a laboratory setting. The scanning electron microscopy (SEM) images of the PLA and PLA/fenugreek composite scaffolds demonstrate the presence of uniform, sleek, and flawless nanofibers. The investigation yielded significant evidence regarding the in vitro wound healing and cell viability of 3 T3 fibroblast cells on the produced scaffolds. The findings demonstrated that PLA scaffolds with fenugreek exhibit promising potential as substitutes for tissue engineering purposes. Graphical Abstract