Exploring the role of diosgenin in modulating RUNX1 and HIPK2 transcription to mitigate Primary Sjögren's Syndrome
Diosgenin effectively impacts immune responses in pSS, potentially through the modulation of RUNX1 and HIPK2 transcription factors, leading to a reduction in Th17-mediated inflammation.
Authors
- Minhua Wang
- Meijia Li (ORCID: https://orcid.org/0009-0003-6495-2748)
- Pengfei Cheng (ORCID: https://orcid.org/0000-0002-4428-3925)
- Liang Wei (ORCID: https://orcid.org/0000-0002-6818-3371)
- Han Liu (ORCID: https://orcid.org/0000-0002-7731-8258)
- Yan Xing (ORCID: https://orcid.org/0000-0003-2150-1448)
- Yiwei Pan
- Fang Wang (ORCID: https://orcid.org/0009-0000-3791-5544)
Institutions
- Capital Medical University (CN)
- Wangjing Hospital of China Academy of Chinese Medical Sciences (CN)
- China Academy of Chinese Medical Sciences (CN)
- Beijing Friendship Hospital (CN)
Publication Details
- Journal
- Immunobiology
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1016/j.imbio.2025.152910
- Primary Topic
- Salivary Gland Disorders and Functions
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- China Academy of Chinese Medical Sciences