FTO downregulation-mediated m6A modification resulting in enhanced hepatocellular carcinoma invasion
Our findings suggest that elevated m6A levels are associated with poor prognosis in HCC patients. FTO downregulation contributes to aberrant m6A modifications, promoting HCC progression and metastasis. FTO acts as a tumor suppressor by negatively regulating VEGFA expression, highlighting its potential as a therapeutic target for HCC treatment. These results highlight the significance of m6A modifications in HCC and provide a foundation for future research on targeted therapies.
Authors
- Yong Zhang (ORCID: https://orcid.org/0000-0001-6316-2734)
- Cheng Zhou (ORCID: https://orcid.org/0000-0002-5005-2285)
- Jian Zhou (ORCID: https://orcid.org/0000-0002-7650-7540)
- Dan Yin (ORCID: https://orcid.org/0000-0002-1888-9835)
- Ying‐Hong Shi (ORCID: https://orcid.org/0000-0002-1833-8988)
- Shi-Ming Shi
- Zheng Wang (ORCID: https://orcid.org/0000-0001-9159-047X)
- Qing Chen (ORCID: https://orcid.org/0000-0001-6229-8568)
- Xuedong Li (ORCID: https://orcid.org/0000-0002-1872-4213)
Institutions
- Sun Yat-sen University (CN)
- Guangdong Medical College (CN)
- Fudan University (CN)
- Zhongshan Hospital (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- Ministry of Education (ET)
- State Key Laboratory of Genetic Engineering
Publication Details
- Journal
- Cell & Bioscience
- Published
- 2025-05-02
- DOI
- https://doi.org/10.1186/s13578-025-01395-w
- Citations
- 6
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 4.84
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China