SARS-CoV-2 humoral immune responses in convalescent individuals over 12 months reveal severity-dependent antibody dynamics
Hospitalized participants initially develop higher anti-SARS-CoV-2 antibody titers that decline faster relative to non-hospitalized participants. While anti-N titers fall below control levels in some participants, anti-RBD titers remain above controls over 12 months, demonstrating long-lived antibody responses known to protect against severe disease. These findings advance our understanding of COVID-19 antibody dynamics.
Authors
- Todd Triplett (ORCID: https://orcid.org/0000-0001-5494-6510)
- Blaine Caslin (ORCID: https://orcid.org/0000-0002-4658-2945)
- Sam Bazzi (ORCID: https://orcid.org/0000-0001-5951-9243)
- Kerin Hurley
- Lauren I. R. Ehrlich (ORCID: https://orcid.org/0000-0002-1697-1755)
- Esther Melamed (ORCID: https://orcid.org/0000-0001-5571-3591)
- Dzifa Amengor (ORCID: https://orcid.org/0000-0001-5705-3259)
- Justin F. Rousseau (ORCID: https://orcid.org/0000-0002-2817-9124)
- Annalee W. Nguyen (ORCID: https://orcid.org/0000-0003-1268-7164)
- Maisey Schuler (ORCID: https://orcid.org/0009-0007-0461-6151)
- Cole Maguire (ORCID: https://orcid.org/0000-0001-8986-9762)
- Jennifer A. Maynard (ORCID: https://orcid.org/0000-0002-0363-8486)
- Christopher DiPasquale
- Rebecca E Wilen
- Melissa Abigania
- Dennis Wylie (ORCID: https://orcid.org/0000-0003-0380-3549)
- Eric N. Olson (ORCID: https://orcid.org/0000-0003-1151-8262)
- Stephen M. Strakowski (ORCID: https://orcid.org/0000-0003-2837-6280)
- Janelle Creaturo
- Jacob E. Rogers
- Nadia Siles Alvarado
Institutions
- Texas Tech University (US)
- Seton Medical Center (US)
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
- The University of Texas at Austin (US)
- The University of Texas Southwestern Medical Center (US)
- Texas Tech University Health Sciences Center (US)
- Babson College (US)
Publication Details
- Journal
- Communications Medicine
- Published
- 2025-05-02
- DOI
- https://doi.org/10.1038/s43856-025-00828-4
- Citations
- 6
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 8.38
Funders
- National Science Foundation
- Amgen
- Advanced Micro Devices
- Cancer Prevention and Research Institute of Texas
- Division of Intramural Research, National Institute of Allergy and Infectious Diseases
- University of Texas at Austin
- Sunovion
- American Academy of Physical Medicine and Rehabilitation
- National Institutes of Health
- Genentech
- University of Texas MD Anderson Cancer Center
- Dell Medical School, University of Texas at Austin
- National Institute on Alcohol Abuse and Alcoholism
- National Institute on Aging
- National Institute of Mental Health
- National Institute of Allergy and Infectious Diseases