Decoding per- and polyfluoroalkyl substances (PFAS) in hepatocellular carcinoma: a multi-omics and computational toxicology approach
Our study highlights key molecular targets and pathways involved in PFAS-induced liver carcinogenesis and proposes a robust survival risk model (PFASRHSig) for HCC. These findings provide new insights into PFAS toxicity mechanisms and offer potential therapeutic targets for mitigating the health risks associated with PFAS exposure. Collectively, our findings help in advancing clinical applications by providing insights into disease mechanisms and potential therapeutic interventions.
Authors
- Deqi Wang
- Jiajun Li (ORCID: https://orcid.org/0009-0008-3475-7868)
- Zeyu Liu (ORCID: https://orcid.org/0000-0003-4377-1780)
- Yuxin Chen (ORCID: https://orcid.org/0000-0001-5955-687X)
- Yanggang Hong (ORCID: https://orcid.org/0009-0003-7220-1207)
- Yi Wang (ORCID: https://orcid.org/0000-0001-9081-120X)
Institutions
- Wenzhou Medical University (CN)
- First Affiliated Hospital of Wenzhou Medical University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-05-02
- DOI
- https://doi.org/10.1186/s12967-025-06517-z
- Citations
- 35
- Primary Topic
- Per- and polyfluoroalkyl substances research
- Type
- article
- Field-Weighted Citation Impact
- 30.09
Funders
- National College Students Innovation and Entrepreneurship Training Program