Resistance exercise combined with protein supplementation for skeletal muscle mass in people with pancreatic cancer undergoing neoadjuvant chemotherapy: Study protocol for the REBUILD trial
The REBUILD trial is the first randomized controlled trial that combines resistance exercise with daily protein supplementation during neoadjuvant chemotherapy in pancreatic cancer patients. Our novel home-based virtually supervised exercise intervention seeks to mitigate barriers to participation in this vulnerable population. Furthermore, results of this trial will address important research gaps associated with pancreatic cancer-related cachexia, a condition closely connected with poor prognosis and mortality.
Authors
- Amber J. Normann (ORCID: https://orcid.org/0000-0002-2397-7063)
- Paola Gonzalo‐Encabo (ORCID: https://orcid.org/0000-0001-5793-1437)
- Jeffrey A. Meyerhardt (ORCID: https://orcid.org/0000-0002-1120-0898)
- Lauren K. Brais (ORCID: https://orcid.org/0000-0003-1069-0407)
- Michael H. Rosenthal (ORCID: https://orcid.org/0000-0002-5085-3904)
- Christina M. Dieli‐Conwright (ORCID: https://orcid.org/0000-0001-9093-7259)
- Brian M. Wolpin (ORCID: https://orcid.org/0000-0002-0455-1032)
- Danny Nguyen (ORCID: https://orcid.org/0000-0002-2479-2271)
- Rebekah L. Wilson (ORCID: https://orcid.org/0000-0003-1704-3624)
- Nathan H. Parker (ORCID: https://orcid.org/0000-0002-8947-7942)
- Hajime Uno (ORCID: https://orcid.org/0000-0003-0622-8471)
- Mary K. Norris (ORCID: https://orcid.org/0000-0002-8914-1306)
- Darryl Tjogas
- John Gardiner
Institutions
- Boston University (US)
- Brigham and Women's Hospital (US)
- Harvard University (US)
- Universidad de Alcalá (ES)
- Moffitt Cancer Center (US)
- Dana-Farber Cancer Institute (US)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-05-02
- DOI
- https://doi.org/10.1371/journal.pone.0322192
- Citations
- 3
- Primary Topic
- Nutrition and Health in Aging
- Type
- article
- Field-Weighted Citation Impact
- 3.49
Funders
- National Institutes of Health