Extracellular vesicles therapy alleviates cisplatin-ınduced testicular tissue toxicity in a rat model
EVs protect against cisplatin-induced reproductive toxicity by modulating oxidative stress and autophagy pathways, preserving testicular function and fertility. These findings suggest that EVs may be a promising therapeutic strategy for mitigating cisplatin's negative effects on reproductive health. Further exploration of dosing regimens and localized applications is recommended for improved efficacy.
Authors
- Zeynep Burçin Gönen (ORCID: https://orcid.org/0000-0003-2725-9330)
- Arzu Hanım YAY (ORCID: https://orcid.org/0000-0002-0541-8372)
- Kübra Tuğçe Kalkan (ORCID: https://orcid.org/0000-0001-7461-277X)
- Halime Tozak Yıldız
- Gözde Özge Önder (ORCID: https://orcid.org/0000-0002-0515-9286)
- Numan Baydilli (ORCID: https://orcid.org/0000-0003-1017-3653)
- Eda Köseoğlu (ORCID: https://orcid.org/0000-0002-0502-7814)
- Özge Cengiz Mat (ORCID: https://orcid.org/0000-0003-4638-6116)
Institutions
- Ahi Evran University (TR)
- Erciyes University (TR)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-05-02
- DOI
- https://doi.org/10.1371/journal.pone.0314093
- Citations
- 8
- Primary Topic
- Chemotherapy-induced organ toxicity mitigation
- Type
- article
- Field-Weighted Citation Impact
- 10.30