Studying the Role of Myenteric Amyloidosis in Gastrointestinal Dysmotility and Enteric Neural Dysfunction Using <scp>APP</scp>/<scp>PS1</scp> Mice—Is It an Adequate Animal Model?
APP/PS1 mice do not recapitulate myenteric amyloidosis persistently and lack the phenotype of constipation observed in human AD patients; these mice should not be considered an adequate murine model for studying the role of myenteric amyloidosis in GI dysmotility. An adequate animal model with myenteric amyloidosis is required for further study.
Authors
- Emma D Flood
- Ryan Mui (ORCID: https://orcid.org/0000-0003-0543-0993)
- Nikitha Srikrishna
- Theresa A. Lansdell (ORCID: https://orcid.org/0000-0001-5523-4080)
- Anne McLaren Dorrance (ORCID: https://orcid.org/0000-0001-6573-2729)
- Marlene Masino
- Hui Xu (ORCID: https://orcid.org/0000-0003-0934-6916)
- James J. Galligan (ORCID: https://orcid.org/0000-0001-7882-5596)
- Roxanne Fernandes
Institutions
- Sparrow Health System (US)
- Michigan State University (US)
Publication Details
- Journal
- Neurogastroenterology & Motility
- Published
- 2025-05-02
- DOI
- https://doi.org/10.1111/nmo.70056
- Primary Topic
- Gastrointestinal motility and disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health
- National Institute of Diabetes and Digestive and Kidney Diseases