Intervening Mechanisms of Amitriptyline Combined With Domperidone on Functional Dyspepsia Rats
The combination of amitriptyline and domperidone relieves anxiety and depression, improves gastrointestinal motility by targeting the 5-HT2BR, PLCβ<sub>2</sub>, and IP<sub>3</sub>R signaling pathways, and modulates the gut microbiota. This integrated approach alleviates FD symptoms through multiple mechanisms and pathways, presenting a promising therapeutic strategy.
Authors
- Xueyun He (ORCID: https://orcid.org/0000-0002-2789-8338)
- Yong Tao (ORCID: https://orcid.org/0000-0002-1351-2094)
- Xu Pei (ORCID: https://orcid.org/0000-0002-3011-9331)
- Yue Ma
- Yudong Wang
- Yanyu Lü (ORCID: https://orcid.org/0000-0003-0096-2712)
- Hongfang Li (ORCID: https://orcid.org/0000-0002-0153-1394)
- Jingyan Gu
- Xinzhong Hao (ORCID: https://orcid.org/0000-0002-6310-5307)
Institutions
- Gansu University of Traditional Chinese Medicine (CN)
- Lanzhou University (CN)
Publication Details
- Journal
- Neurogastroenterology & Motility
- Published
- 2025-05-02
- DOI
- https://doi.org/10.1111/nmo.70070
- Citations
- 2
- Primary Topic
- Gastrointestinal motility and disorders
- Type
- article
- Field-Weighted Citation Impact
- 3.62
Funders
- National Natural Science Foundation of China