Benzaldehyde suppresses epithelial-mesenchymal plasticity and overcomes treatment resistance in cancer by targeting the interaction of 14-3-3ζ with H3S28ph
The interaction between 14-3-3ζ and H3S28ph plays a key role in EMP and treatment resistance in cancer. The ability of BA to inhibit this and other interactions of 14-3-3ζ offers the potential to overcome treatment resistance and to suppress metastasis.
Authors
- Hiroyuki Nobusue (ORCID: https://orcid.org/0000-0003-1341-0298)
- Oltea Sampetrean (ORCID: https://orcid.org/0000-0001-5783-1049)
- Hideyuki Saya (ORCID: https://orcid.org/0000-0001-6610-1902)
- Eiji Sugihara (ORCID: https://orcid.org/0000-0002-3233-1045)
- Yuji Otsuki (ORCID: https://orcid.org/0000-0002-1853-7514)
- Naoyoshi Koike (ORCID: https://orcid.org/0000-0003-1952-0252)
- Takatsune Shimizu (ORCID: https://orcid.org/0000-0003-0161-068X)
- Juntaro Yamasaki (ORCID: https://orcid.org/0000-0002-9697-2810)
- Yukie Hata
- Jun Saito
- Nobuyuki Onishi
- Shogo Okazaki
- Kiyomi Kimura
Institutions
- Nihon University (JP)
- SHOWA Medical University (JP)
- Fujita Health University (JP)
- Keio University (JP)
- University of Electro-Communications (JP)
- Juntendo University (JP)
- Hoshi University (JP)
- Tokyo Dental College Ichikawa General Hospital (JP)
- Keio University Hospital (JP)
- Fujita Health University Hospital (JP)
- Ichikawa City Rehabilitation Hospital (JP)
Publication Details
- Journal
- British Journal of Cancer
- Published
- 2025-05-02
- DOI
- https://doi.org/10.1038/s41416-025-03006-4
- Citations
- 6
- Primary Topic
- Macrophage Migration Inhibitory Factor
- Type
- article
- Field-Weighted Citation Impact
- 4.78
Funders
- University of Cincinnati
- Keio University
- College of Medicine, University of Cincinnati
- Japan Society for the Promotion of Science
- RIKEN