Association of Cortical Atrophy Patterns With Clinical Phenotypes and Histopathological Findings in Patients With Rasmussen Syndrome
Using Rasmussen syndrome as a model, we validate imaging-based mapping of individual disease epicenters with histopathologic evidence. With further validation, network-based mapping of individual disease epicenters could potentially be used in Rasmussen syndrome to guide biopsy site selection, inform treatment decisions, and improve outcome prognoses.
Authors
- Kerstin Alexandra Klotz (ORCID: https://orcid.org/0000-0002-1601-5384)
- Albert J. Becker (ORCID: https://orcid.org/0000-0003-2661-3705)
- Boris C. Bernhardt (ORCID: https://orcid.org/0000-0001-9256-6041)
- Louisa Specht‐Riemenschneider
- Hartmut Vatter (ORCID: https://orcid.org/0000-0001-9999-7282)
- Julika Pitsch (ORCID: https://orcid.org/0000-0002-6688-4916)
- Nina R. Held (ORCID: https://orcid.org/0009-0009-9858-2945)
- Valeri Borger (ORCID: https://orcid.org/0000-0002-5905-4121)
- Tobias Bauer (ORCID: https://orcid.org/0000-0002-0555-6214)
- Lennart Walger (ORCID: https://orcid.org/0000-0002-3300-6877)
- Christoph Helmstaedter (ORCID: https://orcid.org/0000-0002-6608-6244)
- Johannes Reiter (ORCID: https://orcid.org/0000-0002-4235-8209)
- Angela M. Kaindl (ORCID: https://orcid.org/0000-0001-9454-206X)
- Christian Hoppe (ORCID: https://orcid.org/0000-0001-7136-6577)
- Rainer Surges (ORCID: https://orcid.org/0000-0002-3177-8582)
- Alexander Radbruch (ORCID: https://orcid.org/0000-0001-6238-6525)
- Anna Tietze (ORCID: https://orcid.org/0000-0002-2601-9055)
- Theodor Rüber (ORCID: https://orcid.org/0000-0002-6180-7671)
Institutions
- Montreal Neurological Institute and Hospital (CA)
- University of Bonn (DE)
- University Hospital Bonn (DE)
- German Center for Neurodegenerative Diseases (DE)
- McGill University (CA)
- Charité - Universitätsmedizin Berlin (DE)
Publication Details
- Journal
- Neurology
- Published
- 2025-05-02
- DOI
- https://doi.org/10.1212/wnl.0000000000213629
- Citations
- 2
- Primary Topic
- Neonatal and fetal brain pathology
- Type
- article
- Field-Weighted Citation Impact
- 6.99