Cardio-oncology Outcomes in Ultrasound-assisted Versus Standard Catheter-directed Thrombolysis for Acute Pulmonary Embolus
Acute pulmonary embolism (PE) is the third leading cause of cardiovascular death, claiming the lives of over 100,000 people annually in the United States alone.1 Systemic thrombolysis (ST) remains the traditional treatment for high-risk PE, although its effectiveness in reaching the clot can be limited, and its safety can be significantly challenged by major bleeding (including up to 1.5% intracranial bleeding). Catheter-directed therapy (CDT) is a newer and more targeted technique in which thrombolytics are directly applied onto the thrombus of intermediate and high-risk PE using standard catheter-directed thrombolysis (SCDT) and ultrasound-assisted thrombolysis (USAT), with the latter consisting of high-frequency acoustics added to SCDT to improve thrombolytic penetration for greater dissociation of fibrin strands.
Authors
- Kevin A. Honan (ORCID: https://orcid.org/0000-0002-8014-2986)
- K. Mackay (ORCID: https://orcid.org/0009-0000-7034-4923)
- Salman Arain (ORCID: https://orcid.org/0000-0002-5810-4991)
- Teodora Donisan (ORCID: https://orcid.org/0000-0002-1067-1081)
- Hyeon‐Ju Ali (ORCID: https://orcid.org/0000-0002-3378-9154)
- Konstantinos Charitakis
- Arashk Motiei
- Mehmet Çilingiroğlu (ORCID: https://orcid.org/0000-0003-3795-8645)
- Jaime Caballero
- Dominique Monlezun (ORCID: https://orcid.org/0000-0001-7671-1886)
- Dinu Valentin Balanescu (ORCID: https://orcid.org/0000-0001-9293-7535)
- Konstantinos Marmagkiolis (ORCID: https://orcid.org/0000-0001-9620-7142)
- Brenden Ingraham (ORCID: https://orcid.org/0000-0002-8087-2620)
- Konstantinos Dean Boudoulas (ORCID: https://orcid.org/0000-0003-0625-8750)
- Abdelrahman Ali
- Cezar Iliescu
Institutions
- Mayo Clinic (US)
- Ochsner Health System (US)
- The University of Texas MD Anderson Cancer Center (US)
- University of South Florida (US)
- Tampa General Hospital (US)
- The University of Texas Health Science Center (US)
- The Ohio State University (US)
Publication Details
- Journal
- Journal of the Society for Cardiovascular Angiography & Interventions
- Published
- 2025-05-02
- DOI
- https://doi.org/10.1016/j.jscai.2025.103659
- Primary Topic
- Venous Thromboembolism Diagnosis and Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00