Transmembrane thiol isomerase TMX1 inhibits fibrin formation by down-regulation of platelet phosphatidylserine exposure
Together, our observations for the first time demonstrate that TMX1 inhibits PS exposure in platelets downregulating the procoagulant activity, by which TMX1 plays a critical role in maintaining vascular quiescence.
Authors
- Yaqiong Zhang (ORCID: https://orcid.org/0000-0003-2526-1824)
- Zhenzhen Zhao (ORCID: https://orcid.org/0000-0002-6381-711X)
- Yi Lu
- Yi Wu (ORCID: https://orcid.org/0000-0002-5116-9266)
- Xuyang Chen
- Yue Han (ORCID: https://orcid.org/0000-0002-7560-7195)
- Aizhen Yang (ORCID: https://orcid.org/0000-0002-8067-4771)
- Yixin Cheng
Institutions
- Soochow University (CN)
- Bioscience (China) (CN)
- Second Affiliated Hospital of Soochow University (CN)
- First Affiliated Hospital of Soochow University (CN)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2025-05-02
- DOI
- https://doi.org/10.1186/s12964-025-02188-x
- Citations
- 3
- Primary Topic
- Erythrocyte Function and Pathophysiology
- Type
- article
- Field-Weighted Citation Impact
- 3.49
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Huazhong University of Science and Technology
- Priority Academic Program Development of Jiangsu Higher Education Institutions
- State Key Laboratory of Radiation Medicine and Protection