Characterization and Clinical Implications of p53 Dysfunction in Patients With Myelodysplastic Syndromes
The identification of nonmutational p53 dysfunction in MDS may lay the foundation for a mechanistic classification of myeloid neoplasms, moving beyond a purely molecular stratification. The recognition of patients with p53 dysfunction is relevant to provide correct disease-risk assessment and interventions, as well as to refine the design of clinical trials.
Authors
- Elena Riva (ORCID: https://orcid.org/0000-0002-0701-3889)
- Francesca Ficara (ORCID: https://orcid.org/0000-0003-1873-1189)
- Elisabetta Sauta (ORCID: https://orcid.org/0000-0002-7830-988X)
- Lionel Adès (ORCID: https://orcid.org/0000-0002-9020-8766)
- Rami S. Komrokji (ORCID: https://orcid.org/0000-0002-1876-5269)
- Saverio D’Amico (ORCID: https://orcid.org/0000-0003-1877-8497)
- Michela Calvi (ORCID: https://orcid.org/0000-0001-8603-5703)
- Pierre Fenaux (ORCID: https://orcid.org/0000-0002-0468-3553)
- Mirco Ponzoni (ORCID: https://orcid.org/0000-0002-6164-4286)
- Serena Ghisletti (ORCID: https://orcid.org/0000-0002-7087-5553)
- Pamela Acha (ORCID: https://orcid.org/0000-0002-4528-1219)
- Lorenzo Dall’Olio (ORCID: https://orcid.org/0000-0002-8907-0034)
- Daoud Rahal
- Domenico Mavilio (ORCID: https://orcid.org/0000-0001-6147-0952)
- Alessia Campagna (ORCID: https://orcid.org/0000-0002-8481-759X)
- Matteo Zampini (ORCID: https://orcid.org/0000-0002-9952-1142)
- Daniel Remondini (ORCID: https://orcid.org/0000-0003-3185-7456)
- Gastone Castellani (ORCID: https://orcid.org/0000-0003-4892-925X)
- David Andrew Sallman (ORCID: https://orcid.org/0000-0003-0504-8233)
- Giorgio Alberto Croci (ORCID: https://orcid.org/0000-0001-5979-7841)
- Erica Travaglino (ORCID: https://orcid.org/0000-0003-4985-339X)
- Matteo Brindisi (ORCID: https://orcid.org/0000-0002-5022-9642)
- Torsten Haferlach (ORCID: https://orcid.org/0000-0003-0196-2837)
- Cristina Astrid Tentori (ORCID: https://orcid.org/0000-0002-1728-368X)
- Austin Gladston Kulasekararaj (ORCID: https://orcid.org/0000-0003-3180-3570)
- Enrico Lugli (ORCID: https://orcid.org/0000-0002-1964-7678)
- Rita Antunes Dos Reis (ORCID: https://orcid.org/0000-0002-0182-6694)
- Emanuela Boveri (ORCID: https://orcid.org/0000-0002-4932-3527)
- Shahram Kordasti (ORCID: https://orcid.org/0000-0002-0347-4207)
- Alessandra Merlotti (ORCID: https://orcid.org/0000-0002-3648-2828)
- Alessandro Frigo (ORCID: https://orcid.org/0000-0002-7803-8549)
- Umberto Gianelli (ORCID: https://orcid.org/0000-0003-3304-8417)
- Francesco Pesce (ORCID: https://orcid.org/0000-0002-2882-4226)
- Gabriele Todisco (ORCID: https://orcid.org/0000-0001-6583-3829)
- Francesco Nicassio (ORCID: https://orcid.org/0000-0002-5954-5318)
- Guillermo Garcia‐Manero (ORCID: https://orcid.org/0000-0002-3631-2482)
- María Díez‐Campelo (ORCID: https://orcid.org/0000-0002-1467-6779)
- Amer Methqal Zeidan (ORCID: https://orcid.org/0000-0001-7017-8160)
- Alberto Termanini (ORCID: https://orcid.org/0000-0002-9697-906X)
- D Ventura
- Marta Ubezio (ORCID: https://orcid.org/0000-0003-3862-7119)
- Clara Di Vito (ORCID: https://orcid.org/0000-0001-7248-1710)
- Uwe Platzbecker (ORCID: https://orcid.org/0000-0003-1863-3239)
- Françesc Solé (ORCID: https://orcid.org/0000-0002-3251-2161)
- Laura Crisafulli (ORCID: https://orcid.org/0000-0002-1393-5652)
- Ettore Mosca (ORCID: https://orcid.org/0000-0002-3102-5150)
- Arturo Bonometti (ORCID: https://orcid.org/0000-0003-3258-0727)
- Giulia Maggioni (ORCID: https://orcid.org/0000-0002-8652-4854)
- Rossella Caselli
- Luca Lanino (ORCID: https://orcid.org/0000-0003-2404-8829)
- Matteo Giovanni Della Porta (ORCID: https://orcid.org/0000-0002-6915-5970)
- Valeria Santini (ORCID: https://orcid.org/0000-0002-5439-2172)
- Gianluca Asti (ORCID: https://orcid.org/0009-0006-9078-6482)
- Alessandro Buizza
- Mattia Delleani (ORCID: https://orcid.org/0009-0004-1136-0930)
- Antonio Dello Russo (ORCID: https://orcid.org/0000-0002-4370-2008)
- Armando Santoro (ORCID: https://orcid.org/0000-0003-1709-9492)
- Rosa Andres Ejarque (ORCID: https://orcid.org/0000-0003-0012-1155)
- Serena Albertazzi (ORCID: https://orcid.org/0000-0002-6908-4607)
- Nicole Pinocchio
Institutions
- Marche Polytechnic University (IT)
- Guy's Hospital (GB)
- Humanitas University (IT)
- The University of Texas MD Anderson Cancer Center (US)
- Vita-Salute San Raffaele University (IT)
- King's College London (GB)
- University of Milan (IT)
- Université Paris Cité (FR)
- Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT)
- Moffitt Cancer Center (US)
- Italian Institute of Technology (IT)
- Yale University (US)
- Josep Carreras Leukaemia Research Institute (ES)
- Munich Leukemia Laboratory (Germany) (DE)
- Complejo Hospitalario de Salamanca (ES)
- Vall d'Hebron Institut de Recerca (ES)
- King's College Hospital NHS Foundation Trust (GB)
- Human Technopole (IT)
- Institute of Genetic and Biomedical Research (IT)
- Azienda USL di Bologna (IT)
- University Hospital Leipzig (DE)
- Hôpital Saint-Louis (FR)
- Center for Genomic Science (IT)
- Policlinico San Matteo Fondazione (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Institute of Biomedical Technologies (IT)
- National Research Council (IT)
- IRCCS Humanitas Research Hospital (IT)
- Vall d'Hebron Institute of Oncology (ES)
- Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele (IT)
- University of Florence (IT)
- European Institute of Oncology (IT)
- University of Bologna (IT)
Publication Details
- Journal
- Journal of Clinical Oncology
- Published
- 2025-05-02
- DOI
- https://doi.org/10.1200/jco-24-02394
- Citations
- 12
- Primary Topic
- Acute Myeloid Leukemia Research
- Type
- article
- Field-Weighted Citation Impact
- 21.24