Effects of the Quinone Analog Ubiquinone-5 on Murine Mitochondria and Hypnosis
The data indicate that uncompensated mitochondrial proton leak is an important mechanistic contributor to the anesthetic response in addition to electron transport inhibition. These findings advance the authors' understanding of how anesthetics induce hypnosis and lay the foundation for next-generation drug discovery.
Authors
- Max B. Kelz (ORCID: https://orcid.org/0000-0002-2803-6078)
- Keren K. Griffiths (ORCID: https://orcid.org/0000-0003-2482-631X)
- Hyun‐Suk Lim (ORCID: https://orcid.org/0000-0003-4083-2998)
- Fereshteh Zandkarimi (ORCID: https://orcid.org/0000-0001-8618-3669)
- Andrzej Z. Wasilczuk (ORCID: https://orcid.org/0000-0002-1492-2319)
- Yash R. Somnay
- Matthias Quick (ORCID: https://orcid.org/0000-0002-8620-827X)
- Richard J. Levy (ORCID: https://orcid.org/0000-0002-3406-5836)
- Eva Gil‐Iturbe (ORCID: https://orcid.org/0000-0002-4046-5756)
- Anna Moon (ORCID: https://orcid.org/0000-0002-6587-4425)
- Guang Yang (ORCID: https://orcid.org/0000-0002-5739-9126)
- Kai Chen (ORCID: https://orcid.org/0000-0001-7708-0705)
- Aili Wang (ORCID: https://orcid.org/0000-0002-8124-9697)
- Mu Yang (ORCID: https://orcid.org/0000-0003-0091-0365)
- David Larr
Institutions
- Columbia University Irving Medical Center (US)
- New York Psychoanalytic Society and Institute (US)
- New York State Psychiatric Institute
- Columbia University (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- Anesthesiology
- Published
- 2025-05-02
- DOI
- https://doi.org/10.1097/aln.0000000000005549
- Citations
- 3
- Primary Topic
- Anesthesia and Neurotoxicity Research
- Type
- article
- Field-Weighted Citation Impact
- 3.96