Molecular Characterization and Clinical Outcomes of Pancreatic Neuroendocrine Neoplasms Harboring PAK4-NAMPT Alterations
Our study demonstrates that PAK4-high/NAMPT-high pNENs are associated with distinct molecular and immune profiles. Further investigation is warranted to determine if dual PAK4 and NAMPT blockade enhances the efficacy of immunotherapeutics.
Authors
- Ramzi M. Mohammad (ORCID: https://orcid.org/0000-0003-0232-9101)
- Philip A. Philip (ORCID: https://orcid.org/0000-0002-6513-3491)
- Sahar F. Bannoura (ORCID: https://orcid.org/0009-0008-1832-902X)
- Alex Farrell (ORCID: https://orcid.org/0000-0001-5702-3906)
- Sanjay Goel (ORCID: https://orcid.org/0000-0002-2798-7568)
- Khalil Choucair (ORCID: https://orcid.org/0000-0001-8145-3754)
- Husain Yar Khan (ORCID: https://orcid.org/0000-0002-9161-1514)
- Boris Pasche (ORCID: https://orcid.org/0000-0002-3750-7898)
- Herbert Chen (ORCID: https://orcid.org/0000-0003-2923-6079)
- Jeffrey Swensen (ORCID: https://orcid.org/0000-0002-8204-4220)
- Matthew James Oberley (ORCID: https://orcid.org/0000-0001-6419-2513)
- Heloisa P. Soares (ORCID: https://orcid.org/0000-0002-5185-2583)
- Bassel F. El‐Rayes (ORCID: https://orcid.org/0000-0002-2661-5746)
- Misako Nagasaka (ORCID: https://orcid.org/0000-0001-5308-615X)
- Md. Hafiz Uddin (ORCID: https://orcid.org/0000-0002-0188-6857)
- Emil Lou (ORCID: https://orcid.org/0000-0002-1607-1386)
- Nishant Gandhi (ORCID: https://orcid.org/0009-0003-0560-5543)
- Anthony F. Shields (ORCID: https://orcid.org/0000-0002-9122-1014)
- Wafik S. El‐Deiry (ORCID: https://orcid.org/0000-0002-9577-8266)
- Irfana Muqbil (ORCID: https://orcid.org/0000-0001-6889-7035)
- Nikhil Vojjala (ORCID: https://orcid.org/0000-0001-7238-1058)
- Bassel Nazha (ORCID: https://orcid.org/0000-0001-6385-1329)
- Moh’d Khushman (ORCID: https://orcid.org/0000-0002-3095-5073)
- Ibrahim Azar (ORCID: https://orcid.org/0000-0002-1008-1807)
- Jun Gong (ORCID: https://orcid.org/0000-0001-8713-1406)
- Chadi Nabhan (ORCID: https://orcid.org/0000-0003-1740-299X)
Institutions
- Emory University (US)
- Henry Ford Health System (US)
- Wayne State University (US)
- University of California, Irvine (US)
- University of Utah (US)
- Lawrence Technological University (US)
- Brown University (US)
- University of Alabama at Birmingham (US)
- The Barbara Ann Karmanos Cancer Institute (US)
- Trinity Health Oakland Hospital (US)
- University of Minnesota Medical Center (US)
- Caris Life Sciences (United States) (US)
Publication Details
- Journal
- JCO oncology advances.
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1200/oa-24-00032
- Citations
- 1
- Primary Topic
- Neuroendocrine Tumor Research Advances
- Type
- article
- Field-Weighted Citation Impact
- 1.35