Analysis of woodchuck hepatitis virus dynamics in the woodchuck-WHV infection model during acute versus chronic infection, before and after antiviral treatment
The antiviral effects of Entecavir (ETV) against woodchuck hepatitis virus (WHV) and human hepatitis B virus (HBV) are well established. However, the dynamics of hepadnaviral diversity during disease progression and treatment are not well characterized. We aim to infect woodchucks with WHV followed by serial collection of blood and liver biopsy to assess pathogenesis and hepadnaviral quasispecies with or without ETV treatment. This study will inform the understanding of hepadnaviral reactivation risks after stopping ETV.
Authors
- Shanti S. D’Souza (ORCID: https://orcid.org/0000-0001-5542-4511)
- C N Jenne
- CS Coffin
- A Chen
- Douglas P. Whiteside (ORCID: https://orcid.org/0000-0002-4447-9418)
- Tomasz I. Michalak (ORCID: https://orcid.org/0000-0003-1438-0588)
- Guido van Marle (ORCID: https://orcid.org/0000-0002-5148-6229)
- Frank van der Meer (ORCID: https://orcid.org/0000-0003-3785-9639)
- Md. Touhidul Islam (ORCID: https://orcid.org/0000-0003-3206-0326)
- JL Rothenburger
- T Wilayat
Institutions
- Memorial University of Newfoundland (CA)
- University of Calgary (CA)
Publication Details
- Journal
- Peer Beyond Graduate Research Conference
- Published
- 2025-04-29
- DOI
- https://doi.org/10.55016/pbgrc.v1i1.81408
- Primary Topic
- Hepatitis B Virus Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00