Divergent Longitudinal Trajectories and Neurotransmitter Associations of Striatal Subparcellation Spontaneous Activity in Major Depressive Disorder
Spontaneous hyperactivity in the putamen and NAc are reproducible functional imaging markers of MDD. While the hyperactivity of the putamen was responsive to antidepressant treatment, the hyperactivity of the NAc was more trait like. In conclusion, our study revealed both common and divergent spontaneous activity characteristics of the striatum subparcellations in patients with MDD.
Authors
- Kaini Qiao (ORCID: https://orcid.org/0000-0003-0115-6413)
- Zhenxiang Zang (ORCID: https://orcid.org/0000-0002-6865-054X)
- Jing Zhou (ORCID: https://orcid.org/0000-0003-2809-7097)
- Zhi Yang (ORCID: https://orcid.org/0000-0002-2222-2312)
- Gang Wang (ORCID: https://orcid.org/0000-0003-3949-1188)
- Xiongying Chen
Institutions
- Capital Medical University (CN)
- Beijing Anding Hospital (CN)
Publication Details
- Journal
- Biological Psychiatry Global Open Science
- Published
- 2025-05-02
- DOI
- https://doi.org/10.1016/j.bpsgos.2025.100523
- Citations
- 1
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.43
Funders
- Capital Medical University