Cross-Species Evidence for Psilocin-Induced Visual Distortions: Apparent Motion Is Perceived by Both Humans and Rats
Psilocin impaired static-dynamic discrimination in both species, providing the first evidence that rats experience visual distortions similar to those reported by humans. The correlations between discrimination impairment, psilocin levels, and hallucination intensity in humans reinforce psilocin's effects on visual perception. This approach provides a valuable tool for investigating the neurobiology of altered visual perception in drug-induced states and psychiatric conditions.
Authors
- Klára Šíchová (ORCID: https://orcid.org/0000-0003-1653-822X)
- Tereza Nekovářová (ORCID: https://orcid.org/0000-0003-4410-9975)
- Kateřina Syrová (ORCID: https://orcid.org/0000-0003-4091-1303)
- Čestmír Vejmola (ORCID: https://orcid.org/0000-0002-6434-5978)
- M. Nikolič (ORCID: https://orcid.org/0000-0002-2564-7287)
- Jakub Korčák (ORCID: https://orcid.org/0000-0001-5017-4736)
- Filip Tylš (ORCID: https://orcid.org/0000-0002-8337-6999)
- Jiřı́ Horáček (ORCID: https://orcid.org/0000-0003-0114-7306)
- Michaela Viktorinová (ORCID: https://orcid.org/0000-0002-6462-5793)
- Lucie Janečková (ORCID: https://orcid.org/0000-0003-0139-7065)
- Tomáš Páleníček (ORCID: https://orcid.org/0000-0002-3109-9539)
- Eduard Kelemen (ORCID: https://orcid.org/0000-0002-2101-6314)
- Vlastimil Koudelka (ORCID: https://orcid.org/0000-0002-7553-7529)
- Michael Tesař
- Martin Brunovský (ORCID: https://orcid.org/0000-0002-2483-0848)
- Martin Kuchař (ORCID: https://orcid.org/0000-0002-7616-6352)
- Vojtěch Viktorin (ORCID: https://orcid.org/0000-0003-0801-2244)
Institutions
- Charles University (CZ)
- National Institute of Mental Health (JP)
- National Institute of Mental Health (CZ)
- University of Chemistry and Technology, Prague (CZ)
Publication Details
- Journal
- Biological Psychiatry Global Open Science
- Published
- 2025-05-02
- DOI
- https://doi.org/10.1016/j.bpsgos.2025.100524
- Citations
- 4
- Primary Topic
- Psychedelics and Drug Studies
- Type
- article
- Field-Weighted Citation Impact
- 9.23