Safety profile of intracranial neuromodulation for drug-resistant epilepsy in children
To the best of the authors' knowledge, this study represents the largest single-center series of intracranial stimulation for pediatric DRE. In comparison with established rates of SSI and explant in adults (12% and 7.0% in the RNS pivotal trial and 13% and 8.6% in the DBS SANTE [Stimulation of the Anterior Nucleus of the Thalamus for Epilepsy] trial, respectively), the present cohort demonstrated favorable rates of 1.9% and 5.6%, respectively. Studies with larger pediatric DRE cohorts are needed with longer follow-up and seizure outcomes to elucidate the risk/benefit balance of intracranial stimulation in children.
Authors
- Benjamin C. Kennedy (ORCID: https://orcid.org/0000-0002-4446-5243)
- Caren Armstrong (ORCID: https://orcid.org/0000-0001-8010-0850)
- Michelle Han (ORCID: https://orcid.org/0000-0001-9242-3083)
- Susan E. Melamed
- Sudha Kilaru Kessler (ORCID: https://orcid.org/0000-0002-9325-9972)
- Kathleen Galligan
- Marissa DiGiovine
- Shikha Singh (ORCID: https://orcid.org/0000-0002-3492-0070)
Institutions
- Children's Hospital of Philadelphia (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- Journal of Neurosurgery Pediatrics
- Published
- 2025-05-02
- DOI
- https://doi.org/10.3171/2025.1.peds24463
- Citations
- 2
- Primary Topic
- Vagus Nerve Stimulation Research
- Type
- article
- Field-Weighted Citation Impact
- 1.68