The neuronal reserve in glioma surgery: functional reorganization of the motor network examined by navigated transcranial magnetic stimulation and diffusion tensor imaging tractography

This study confirmed prior findings on glioma-induced reorganization of primary motor areas. The association between functional recovery and reorganization, especially resizing and excitability changes, suggests an individual neuronal reserve explaining differences in disease progression. The authors support the extended consideration of navigated transcranial magnetic stimulation data for preoperative risk stratification and patient-tailored treatment strategies.