Investigating the molecular mechanisms and clinical potential of APO+ endothelial cells associated with PANoptosis in the tumor microenvironment of hepatocellular carcinoma using single-cell sequencing data

This study systematically mapped the cellular landscape of the TME in HCC patients and explored the differences in differentiation trajectories, metabolic pathways, and other aspects of subpopulations with high PANoptosis scores. Additionally, the study elucidated the potential molecular mechanisms through which APO+ ECs inhibit HCC cell proliferation and improve prognosis and immunotherapeutic efficacy in HCC patients. This research provides new insights for clinical prognosis evaluation and immunotherapy strategies in HCC.

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Publication Details

Journal
Translational Oncology
Published
2025-05-02
DOI
https://doi.org/10.1016/j.tranon.2025.102402
Citations
2
Primary Topic
Cancer, Hypoxia, and Metabolism
Type
article
Field-Weighted Citation Impact
1.87

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article

Investigating the molecular mechanisms and clinical potential of APO+ endothelial cells associated with PANoptosis in the tumor microenvironment of hepatocellular carcinoma using single-cell sequencing data

Zhaorui Cheng, Jiajun Zheng, Xiaolu Yang, Xiushen Li et al.
2 citations
Translational Oncology
Cancer, Hypoxia, and Metabolism
1.87
article

Investigating the molecular mechanisms and clinical potential of APO+ endothelial cells associated with PANoptosis in the tumor microenvironment of hepatocellular carcinoma using single-cell sequencing data

Zhaorui Cheng, Jiajun Zheng, Xiaolu Yang, Xiushen Li, Tao Xin, Qi Zhang, Huimin Wang, Xiao‐Yong Chen, Xinzhu Liu, Xiangyu Yang, Wenhao Wu, Y L Qian, Yi Ren, Sailing Lin
article en
2 citations

Abstract

This study systematically mapped the cellular landscape of the TME in HCC patients and explored the differences in differentiation trajectories, metabolic pathways, and other aspects of subpopulations with high PANoptosis scores. Additionally, the study elucidated the potential molecular mechanisms through which APO+ ECs inhibit HCC cell proliferation and improve prognosis and immunotherapeutic efficacy in HCC patients. This research provides new insights for clinical prognosis evaluation and immunotherapy strategies in HCC.

Translational OncologyVol. 57
Nanchang University (CN), Sun Yat-sen University (CN), Shenzhen University (CN), Dalian Medical University (CN), Southern University of Science and Technology (CN), Second Affiliated Hospital of Chongqing Medical University (CN), Shenzhen Maternity and Child Healthcare Hospital (CN), Jiangxi Maternal and Child Health Hospital (CN), Second Affiliated Hospital of Nanchang University (CN), Gannan Medical University (CN), Shenzhen University Health Science Center (CN), Eighth Affiliated Hospital of Sun Yat-sen University, Chongqing Medical University (CN)
Natural Science Foundation of Jiangxi Province, Nanchang University
Good health and well-being
Openalex Percentile: Top 15%
Cancer, Hypoxia, and Metabolism
1.87
DOIOpen Access PDFOpenAlex
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