Formononetin suppresses colitis-associated colon cancer by targeting lipid synthesis and mTORC2/Akt signaling
FN significantly inhibits colon cancer cell growth and exerts anti-CAC effects by activating autophagy and apoptosis pathways and regulating lipid metabolism. This study is the first to comprehensively integrate metabolomics, intestinal flora analysis, and molecular mechanisms to unveil FN's multifaceted role in CAC treatment, offering novel insights into its therapeutic application.
Authors
- M. Liu (ORCID: https://orcid.org/0009-0005-9970-2188)
- Yanping Li (ORCID: https://orcid.org/0000-0002-2409-3569)
- Chung S. Yang (ORCID: https://orcid.org/0000-0001-6713-4837)
- Xiaoyuan Peng (ORCID: https://orcid.org/0000-0003-2302-362X)
- Wei‐Guang Wang (ORCID: https://orcid.org/0000-0003-3395-767X)
- Hong‐Ping He
- Shichun Zheng
Institutions
- State Ethnic Affairs Commission (CN)
- Yunnan University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Phytomedicine
- Published
- 2025-05-02
- DOI
- https://doi.org/10.1016/j.phymed.2025.156665
- Citations
- 7
- Primary Topic
- Cancer, Lipids, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 6.55