Molecular targets of vortioxetine mediating glioblastoma suppression revealed by gene and protein network analyses and molecular docking simulations
This study suggests that vortioxetine may inhibit glioblastoma development through direct effects on multiple targets and further emphasizes the value of bioinformatics analyses for drug repositioning.
Authors
- Ranli Li
- Chuanjun Zhuo (ORCID: https://orcid.org/0000-0002-3793-550X)
- Chao Li (ORCID: https://orcid.org/0000-0002-0240-5170)
- Ying Zhang (ORCID: https://orcid.org/0000-0003-1620-3825)
- Lei Yang (ORCID: https://orcid.org/0000-0002-5239-4617)
- Qiuyu Zhang (ORCID: https://orcid.org/0000-0002-4823-5031)
- Ximing Chen (ORCID: https://orcid.org/0000-0002-9079-2755)
- Lina Wang (ORCID: https://orcid.org/0000-0002-5323-5431)
- Xiaoyan Ma (ORCID: https://orcid.org/0009-0007-7953-947X)
- Hongjun Tian (ORCID: https://orcid.org/0000-0002-3919-3749)
Institutions
- Nankai University (CN)
- Tianjin Anding Hospital (CN)
- Tianjin Medical University (CN)
Publication Details
- Journal
- The International Journal of Neuropsychopharmacology
- Published
- 2025-05-02
- DOI
- https://doi.org/10.1093/ijnp/pyaf029
- Citations
- 3
- Primary Topic
- Cancer, Stress, Anesthesia, and Immune Response
- Type
- article
- Field-Weighted Citation Impact
- 4.41
Funders
- National Natural Science Foundation of China