Lactate induces oxidative stress by HIF1α stabilization and circadian clock disturbance in mammary gland of dairy cows
In summary, our study highlights the central role of competitive transcriptional element occupancy in lactate-mediated oxidative stress of mammary gland, which is caused by HIF1α stabilization and circadian rhythm dysfunction. Our findings introduce a novel nutritional strategy with potential applications in dairy farming for optimizing milk production and maintaining mammary gland health.
Authors
- Juan Feng
- Lei Zhu (ORCID: https://orcid.org/0000-0001-5003-9059)
- Cunman He (ORCID: https://orcid.org/0000-0002-6331-6059)
- Ruidong Xiang (ORCID: https://orcid.org/0000-0002-1584-7605)
- Jie Cai (ORCID: https://orcid.org/0000-0002-6561-5626)
- Diming Wang (ORCID: https://orcid.org/0000-0002-1451-6863)
- Jianxin Liu (ORCID: https://orcid.org/0000-0002-5812-5186)
Institutions
- La Trobe University (AU)
- Agriculture Victoria (AU)
- AgriBio (AU)
- Zhejiang University (CN)
Publication Details
- Journal
- Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1186/s40104-025-01181-1
- Citations
- 3
- Primary Topic
- Circadian rhythm and melatonin
- Type
- article
- Field-Weighted Citation Impact
- 2.74
Funders
- National Natural Science Foundation of China
- Zhejiang University