Prevalence and diagnostic dilemma of chromosomal abnormalities in the Niger Delta area of Nigeria; Is prenatal diagnosis worthwhile?
The total number of babies that were delivered by the 5868 participants in the study was 6078, out of which 10 cases of aneuploides were identified - 3 cases of trisomy 18 and 7 cases of Trisomy 21. The prevalence of chromosomal abnormalities at birth at the RSUTH was 0.165% of the total births, 1:2000 and 1:654 for T18 and T21 respectively. 1:654 mothers had babies with chromosomal abnormalities, 1:2000 and 1:833 for T18 and T21 respectively.Conclusion: The prevalence of chromosomal abnormalities at birth at the RSUTH of 0.165% represented a gross underestimation because the diagnosis was based on the outward phenotypical appearance of the neonates and it was made not from babies delivered at 20 weeks and above as practiced in Europe and other countries, but from 28 weeks. Prenatal diagnosis was therefore highly recommended in the Niger Delta.
Authors
- Mkpe Abbey (ORCID: https://orcid.org/0000-0001-5605-9878)
- Boma Awoala West (ORCID: https://orcid.org/0000-0002-9849-1412)
- Uduak Solomon Ocheche
- Faithwin Horsfall
- Paul Ledee Kua
- Olufemi Adebari Oloyede (ORCID: https://orcid.org/0000-0001-6332-9610)
- Leesi Sapira-Ordu
- Nestor Mininyo Inimgba
- Kenneth Eghuan Okagua
- Ngozi J Kwosah
- Simeon Chijioke Amadi
- Nimi Briggs
- Chidiebere Nwakanma Ononuju
- Rose Sitonma Iwo-Amah
- Esther Ijeoma Nonye-Enyidah
- Basil O. Altraide
Institutions
- University of Port Harcourt Teaching Hospital (NG)
- Rivers State University (NG)
Publication Details
- Journal
- PubMed
- Published
- 2024-08-08
- DOI
- https://doi.org/10.71480/nmj.v66i1.561
- Primary Topic
- Prenatal Screening and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00