Migraine manifestations due to correction of secondary hyperhomocysteinaemia

Migraine is one of the most common causes of headache with the prevalence reaching 21% and 6% in females and males, respectively, thereby attracting a great attention in investigating underlying migraine pathogenesis. The current article presents a clinical case of alleviated migraine manifestations in female patient with verified hyperhomocysteinaemia occurred due to severe folic acid deficiency. The additional specific characteristic of this case is associated to asymmetry of venous sinuses, revealed by contrast-free magnetic resonance angiography that accounts for cerebral venous dyscirculation. Hyperhomocysteinaemia is one of the factors of endothelial dysfunction, which impact in different diseases, including cerebrovascular, is being discussed. The data have been collected evidencing about a more frequent incidence of this disorder among patients with migraine than in healthy volunteers. Because hyperhomocysteinaemia may be decreased by medical therapy, it’s detection and correction potentially may alleviate migraine manifestations. This hypothesis require to be further investigated.